Formulation And Evaluation Of Etoricoxib Oro Dispersible Tablets

An attempt has been made for the development of Orodispersible tablet of Etoricoxib by direct compression method.Sodium starch glycolate, Crospovidone, Croscarmellose, and Ludiflashwere used as a Superdisintegrants for the formulation. Twenty formulation having Superdisintegrants at different concentration (3, 6, 9, 12 %) level were prepared using microcrystalline cellulose as a direct compressible vehicle. The prepared batches of tablets were evaluated for Tablet weight variation, content uniformity, hardness, friability. Effects of Superdisintegrants on wetting time, dispersion time, and in vitro release also have been studied in 0.01Hcl buffer medium. Tablet containing Croscarmellose sodium (9%) showed excellent in vitro dispersion time and drug release as compared to other formulation. After the color and flavor optimization study formulations F18 shows short dispersion time (18sec) with maximum drug release in 15 min. FT‐IR & DSC studies revealed that there was no physico‐chemical interaction between Etoricoxib and Superdisintegrants. It is concluded that Oro dispersible Etoricoxib tablets could be prepared by direct compression method using Croscarmellose sodium as Superdisintegrants. Stability study of F18 formulation showed no significant changes in tablet properties.